Drug interactions
Cyclobenzaprine + Dexfenfluramine
Severity: Minor
Cyclobenzaprine and Dexfenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dexfenfluramine is a serotonin-releasing agent that has been withdrawn from the market. Cyclobenzaprine has serotonergic activity, so serotonin syndrome is a theoretical concern, but no well-documented interaction exists.
What this interaction means in plain words
Cyclobenzaprine and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive serotonergic effects; the interaction is not well established.
What to do
Dexfenfluramine is not marketed; if encountered, monitor for agitation, tremor, hyperthermia and other signs of serotonin toxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Dexfenfluramine?
MediHelp rates the interaction as minor. Cyclobenzaprine and Dexfenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dexfenfluramine is a serotonin-releasing agent that has been withdrawn from the market. Cyclobenzaprine has serotonergic activity, so serotonin syndrome is a theoretical concern, but no well-documented interaction exists.
How serious is the interaction between Cyclobenzaprine and Dexfenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Dexfenfluramine is not marketed; if encountered, monitor for agitation, tremor, hyperthermia and other signs of serotonin toxicity.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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