Drug interactions
Cyclobenzaprine + Dextroamphetamine transdermal
Severity: Major
Cyclobenzaprine and Dextroamphetamine transdermal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both cyclobenzaprine, structurally related to tricyclic antidepressants, and amphetamines increase serotonergic activity. Combined use raises the risk of serotonin syndrome, and amphetamines may also add to cardiovascular stimulation.
What this interaction means in plain words
Cyclobenzaprine and Dextroamphetamine transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic activity (serotonin reuptake inhibition and release).
What to do
Start at low doses and monitor for agitation, tremor, hyperthermia, clonus and tachycardia. If serotonin syndrome occurs, stop the amphetamine and the other serotonergic drug.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Dextroamphetamine transdermal?
MediHelp rates the interaction as major. Cyclobenzaprine and Dextroamphetamine transdermal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both cyclobenzaprine, structurally related to tricyclic antidepressants, and amphetamines increase serotonergic activity. Combined use raises the risk of serotonin syndrome, and amphetamines may also add to cardiovascular stimulation.
How serious is the interaction between Cyclobenzaprine and Dextroamphetamine transdermal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start at low doses and monitor for agitation, tremor, hyperthermia, clonus and tachycardia. If serotonin syndrome occurs, stop the amphetamine and the other serotonergic drug.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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