Drug interactions
Cyclobenzaprine + Difenoxin
Severity: Moderate
Cyclobenzaprine and Difenoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Difenoxin is an opioid antidiarrheal and the active metabolite of diphenoxylate. With cyclobenzaprine, sedation may be increased, and additive anticholinergic effects may add to constipation and urinary retention.
What this interaction means in plain words
Cyclobenzaprine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Difenoxin belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Monitor for oversedation, constipation and urinary retention. Avoid exceeding recommended doses of either drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Difenoxin
Frequently asked questions
Can I take Cyclobenzaprine with Difenoxin?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Difenoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Difenoxin is an opioid antidiarrheal and the active metabolite of diphenoxylate. With cyclobenzaprine, sedation may be increased, and additive anticholinergic effects may add to constipation and urinary retention.
How serious is the interaction between Cyclobenzaprine and Difenoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, constipation and urinary retention. Avoid exceeding recommended doses of either drug.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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