Drug interactions
Cyclobenzaprine + Esketamine
Severity: Moderate
Cyclobenzaprine and Esketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is a sedating, tricyclic-like muscle relaxant. Combined with esketamine, drowsiness, dizziness and impaired coordination may increase.
What this interaction means in plain words
Cyclobenzaprine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Esketamine belongs to Central Nervous System.
Why it happens
Additive CNS depression, with anticholinergic and antihistaminic sedative contribution from cyclobenzaprine.
What to do
Monitor sedation during the post-dose observation period. Counsel the patient to avoid driving after treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esketamine
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Esketamine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Esketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is a sedating, tricyclic-like muscle relaxant. Combined with esketamine, drowsiness, dizziness and impaired coordination may increase.
How serious is the interaction between Cyclobenzaprine and Esketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation during the post-dose observation period. Counsel the patient to avoid driving after treatment.
What other medicines interact with Esketamine?
MediHelp also lists interactions of Esketamine with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Esketamine page.
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