Drug interactions
Cyclobenzaprine + Fexinidazole
Severity: Moderate
Cyclobenzaprine and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole and its metabolites may inhibit CYP1A2, a pathway involved in cyclobenzaprine metabolism. Cyclobenzaprine exposure could rise, increasing sedation and anticholinergic effects. Fexinidazole also prolongs QT, and cyclobenzaprine has a possible QT effect.
What this interaction means in plain words
Cyclobenzaprine and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP1A2-mediated cyclobenzaprine metabolism, plus possible additive QT effects.
What to do
Monitor for increased sedation and anticholinergic effects during the short fexinidazole course, and consider an ECG if other QT risks exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Fexinidazole?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole and its metabolites may inhibit CYP1A2, a pathway involved in cyclobenzaprine metabolism. Cyclobenzaprine exposure could rise, increasing sedation and anticholinergic effects. Fexinidazole also prolongs QT, and cyclobenzaprine has a possible QT effect.
How serious is the interaction between Cyclobenzaprine and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and anticholinergic effects during the short fexinidazole course, and consider an ECG if other QT risks exist.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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