Drug interactions
Cyclobenzaprine + Flurazepam
Severity: Moderate
Cyclobenzaprine and Flurazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flurazepam is a long-acting benzodiazepine whose active metabolite accumulates. With cyclobenzaprine, excessive sedation, impaired cognition, falls and respiratory depression are possible.
What this interaction means in plain words
Cyclobenzaprine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and monitor for daytime sedation and falls, especially in elderly patients. Avoid alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Flurazepam?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Flurazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flurazepam is a long-acting benzodiazepine whose active metabolite accumulates. With cyclobenzaprine, excessive sedation, impaired cognition, falls and respiratory depression are possible.
How serious is the interaction between Cyclobenzaprine and Flurazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for daytime sedation and falls, especially in elderly patients. Avoid alcohol.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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