Drug interactions
Cyclobenzaprine + Hyoscyamine spray
Severity: Moderate
Cyclobenzaprine and Hyoscyamine spray: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Hyoscyamine given as an oral spray is absorbed systemically (mostly via mucosa and swallowed drug) and adds to the antimuscarinic load of cyclobenzaprine. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia, and confusion.
What this interaction means in plain words
Cyclobenzaprine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic adverse effects and minimize doses, especially in older adults. Avoid in patients with glaucoma or urinary obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Hyoscyamine spray?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Hyoscyamine spray can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Hyoscyamine given as an oral spray is absorbed systemically (mostly via mucosa and swallowed drug) and adds to the antimuscarinic load of cyclobenzaprine. This may cause dry mouth, constipation, urinary retention, blurred vision, tachycardia, and confusion.
How serious is the interaction between Cyclobenzaprine and Hyoscyamine spray?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects and minimize doses, especially in older adults. Avoid in patients with glaucoma or urinary obstruction.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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