Drug interactions
Cyclobenzaprine + Ketamine
Severity: Moderate
Cyclobenzaprine and Ketamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketamine and cyclobenzaprine both impair alertness and psychomotor performance, and together they may cause deeper sedation. Cyclobenzaprine's anticholinergic effects may add to ketamine-related confusion or agitation.
What this interaction means in plain words
Cyclobenzaprine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Ketamine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects.
What to do
Monitor level of consciousness and respiratory status when combined and reduce doses if oversedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Ketamine
Frequently asked questions
Can I take Cyclobenzaprine with Ketamine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Ketamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketamine and cyclobenzaprine both impair alertness and psychomotor performance, and together they may cause deeper sedation. Cyclobenzaprine's anticholinergic effects may add to ketamine-related confusion or agitation.
How serious is the interaction between Cyclobenzaprine and Ketamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness and respiratory status when combined and reduce doses if oversedation occurs.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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