Drug interactions
Cyclobenzaprine + Levorphanol
Severity: Major
Cyclobenzaprine and Levorphanol: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levorphanol is an opioid and cyclobenzaprine is a sedating muscle relaxant, so using them together can cause profound sedation, respiratory depression, hypotension and impaired psychomotor function. Opioid labeling warns of serious risks including coma and death when combined with other CNS depressants.
What this interaction means in plain words
Cyclobenzaprine and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression.
What to do
Reserve the combination for patients with no alternative, using the lowest doses and shortest duration, and monitor for sedation and respiratory depression. Counsel patients to avoid alcohol and driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Levorphanol?
MediHelp rates the interaction as major. Cyclobenzaprine and Levorphanol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levorphanol is an opioid and cyclobenzaprine is a sedating muscle relaxant, so using them together can cause profound sedation, respiratory depression, hypotension and impaired psychomotor function. Opioid labeling warns of serious risks including coma and death when combined with other CNS depressants.
How serious is the interaction between Cyclobenzaprine and Levorphanol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve the combination for patients with no alternative, using the lowest doses and shortest duration, and monitor for sedation and respiratory depression. Counsel patients to avoid alcohol and driving.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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