Drug interactions
Cyclobenzaprine + Lofepramine
Severity: Major
Cyclobenzaprine and Lofepramine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lofepramine is a tricyclic antidepressant, and cyclobenzaprine is structurally a tricyclic, so the two share anticholinergic, sedative and cardiac conduction effects. Combining them can cause additive drowsiness, anticholinergic toxicity and arrhythmia risk, and serotonergic effects are also possible.
What this interaction means in plain words
Cyclobenzaprine and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive antimuscarinic, sedative, QT/conduction and serotonergic effects of two tricyclic-type compounds.
What to do
Avoid concurrent use where possible; if unavoidable, monitor for anticholinergic toxicity, sedation, serotonin syndrome and arrhythmia, with an ECG in patients at cardiac risk.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Lofepramine?
MediHelp rates the interaction as major. Cyclobenzaprine and Lofepramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lofepramine is a tricyclic antidepressant, and cyclobenzaprine is structurally a tricyclic, so the two share anticholinergic, sedative and cardiac conduction effects. Combining them can cause additive drowsiness, anticholinergic toxicity and arrhythmia risk, and serotonergic effects are also possible.
How serious is the interaction between Cyclobenzaprine and Lofepramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; if unavoidable, monitor for anticholinergic toxicity, sedation, serotonin syndrome and arrhythmia, with an ECG in patients at cardiac risk.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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