Drug interactions
Cyclobenzaprine + Loxapine inhaled
Severity: Moderate
Cyclobenzaprine and Loxapine inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inhaled loxapine is systemically absorbed quickly and has sedative and anticholinergic effects that add to those of cyclobenzaprine. Increased drowsiness, anticholinergic symptoms and bronchospasm risk are the main concerns, and loxapine's use is restricted by a REMS program because of bronchospasm.
What this interaction means in plain words
Cyclobenzaprine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant and antimuscarinic effects of loxapine and cyclobenzaprine.
What to do
Monitor for excess sedation and anticholinergic effects, and give loxapine only in a supervised setting with bronchospasm precautions. Reduce doses or space administration if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Loxapine inhaled?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Loxapine inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Inhaled loxapine is systemically absorbed quickly and has sedative and anticholinergic effects that add to those of cyclobenzaprine. Increased drowsiness, anticholinergic symptoms and bronchospasm risk are the main concerns, and loxapine's use is restricted by a REMS program because of bronchospasm.
How serious is the interaction between Cyclobenzaprine and Loxapine inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and anticholinergic effects, and give loxapine only in a supervised setting with bronchospasm precautions. Reduce doses or space administration if sedation is excessive.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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