Drug interactions
Cyclobenzaprine + Marijuana
Severity: Moderate
Cyclobenzaprine and Marijuana: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis produces sedation, dizziness and impaired psychomotor performance, which add to the sedating effects of cyclobenzaprine. Tachycardia from cannabis may also be additive with the anticholinergic effects of cyclobenzaprine.
What this interaction means in plain words
Cyclobenzaprine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression via cannabinoid receptor activity and cyclobenzaprine's antihistaminic and anticholinergic sedation.
What to do
Advise patients about increased drowsiness and impaired driving, and avoid concurrent use before activities requiring alertness. Reduce the cyclobenzaprine dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Marijuana?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Marijuana can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis produces sedation, dizziness and impaired psychomotor performance, which add to the sedating effects of cyclobenzaprine. Tachycardia from cannabis may also be additive with the anticholinergic effects of cyclobenzaprine.
How serious is the interaction between Cyclobenzaprine and Marijuana?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients about increased drowsiness and impaired driving, and avoid concurrent use before activities requiring alertness. Reduce the cyclobenzaprine dose if sedation is excessive.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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