Drug interactions
Cyclobenzaprine + Methylenedioxymethamphetamine
Severity: Major
Cyclobenzaprine and Methylenedioxymethamphetamine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MDMA releases serotonin massively, and cyclobenzaprine has serotonergic activity and tricyclic-like effects, so the combination raises the risk of serotonin syndrome, hyperthermia and cardiovascular stimulation. Tricyclic-like drugs may also alter MDMA's effects and add to tachycardia and arrhythmia risk.
What this interaction means in plain words
Cyclobenzaprine and Methylenedioxymethamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic and sympathomimetic effects, with possible interference with MDMA's monoamine transporter actions.
What to do
Advise against combining; if exposure occurs, assess for serotonin syndrome, hyperthermia and tachyarrhythmia and provide supportive care including cooling and benzodiazepines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Methylenedioxymethamphetamine?
MediHelp rates the interaction as major. Cyclobenzaprine and Methylenedioxymethamphetamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. MDMA releases serotonin massively, and cyclobenzaprine has serotonergic activity and tricyclic-like effects, so the combination raises the risk of serotonin syndrome, hyperthermia and cardiovascular stimulation. Tricyclic-like drugs may also alter MDMA's effects and add to tachycardia and arrhythmia risk.
How serious is the interaction between Cyclobenzaprine and Methylenedioxymethamphetamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against combining; if exposure occurs, assess for serotonin syndrome, hyperthermia and tachyarrhythmia and provide supportive care including cooling and benzodiazepines.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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