Drug interactions
Cyclobenzaprine + Metoclopramide intranasal
Severity: Moderate
Cyclobenzaprine and Metoclopramide intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine has anticholinergic activity that can oppose the prokinetic effect of metoclopramide. Both drugs can cause CNS effects such as drowsiness, and both are associated with serotonergic or extrapyramidal reactions.
What this interaction means in plain words
Cyclobenzaprine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Anticholinergic antagonism of prokinetic action with overlapping CNS effects.
What to do
Monitor for reduced metoclopramide efficacy, sedation and movement disorders. Consider an alternative muscle relaxant if response is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Metoclopramide intranasal?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Metoclopramide intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine has anticholinergic activity that can oppose the prokinetic effect of metoclopramide. Both drugs can cause CNS effects such as drowsiness, and both are associated with serotonergic or extrapyramidal reactions.
How serious is the interaction between Cyclobenzaprine and Metoclopramide intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced metoclopramide efficacy, sedation and movement disorders. Consider an alternative muscle relaxant if response is poor.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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