Drug interactions
Cyclobenzaprine + Moxonidine
Severity: Moderate
Cyclobenzaprine and Moxonidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Moxonidine is a centrally acting antihypertensive that can cause drowsiness, dry mouth and dizziness, which can add to the sedation and anticholinergic effects of cyclobenzaprine. Additive hypotension may also occur.
What this interaction means in plain words
Cyclobenzaprine and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotensive effects via central imidazoline and alpha-2 activity plus cyclobenzaprine sedation.
What to do
Monitor blood pressure and sedation, especially at initiation or dose changes, and advise caution with driving. Lower the dose of either drug if dizziness or marked drowsiness develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Moxonidine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Moxonidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Moxonidine is a centrally acting antihypertensive that can cause drowsiness, dry mouth and dizziness, which can add to the sedation and anticholinergic effects of cyclobenzaprine. Additive hypotension may also occur.
How serious is the interaction between Cyclobenzaprine and Moxonidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and sedation, especially at initiation or dose changes, and advise caution with driving. Lower the dose of either drug if dizziness or marked drowsiness develops.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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