Drug interactions
Cyclobenzaprine + Olodaterol inhaled
Severity: Moderate
Cyclobenzaprine and Olodaterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine can prolong the QT interval and cause tachycardia, while olodaterol as a beta2-agonist can cause tachycardia, hypokalemia and QT changes. Combined use may increase the risk of ventricular arrhythmia in susceptible patients.
What this interaction means in plain words
Cyclobenzaprine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and cardiostimulatory effects.
What to do
Monitor heart rate and rhythm, and correct potassium and magnesium abnormalities. Consider an ECG in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Olodaterol inhaled?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Olodaterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine can prolong the QT interval and cause tachycardia, while olodaterol as a beta2-agonist can cause tachycardia, hypokalemia and QT changes. Combined use may increase the risk of ventricular arrhythmia in susceptible patients.
How serious is the interaction between Cyclobenzaprine and Olodaterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and rhythm, and correct potassium and magnesium abnormalities. Consider an ECG in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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