Drug interactions
Cyclobenzaprine + Olopatadine intranasal
Severity: Moderate
Cyclobenzaprine and Olopatadine intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and cyclobenzaprine is itself sedating. Together they may add to drowsiness and impair psychomotor performance and next-day alertness.
What this interaction means in plain words
Cyclobenzaprine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression from the sedating antihistamine and the sedating muscle relaxant.
What to do
Counsel patients to avoid driving or hazardous tasks until the combined effect is known, and consider dosing olopatadine away from the cyclobenzaprine dose. Use a non-sedating alternative if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Olopatadine intranasal?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Olopatadine intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause somnolence, and cyclobenzaprine is itself sedating. Together they may add to drowsiness and impair psychomotor performance and next-day alertness.
How serious is the interaction between Cyclobenzaprine and Olopatadine intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving or hazardous tasks until the combined effect is known, and consider dosing olopatadine away from the cyclobenzaprine dose. Use a non-sedating alternative if drowsiness is troublesome.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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