Drug interactions
Cyclobenzaprine + Ombitasvir / paritaprevir / ritonavir and dasabuvir
Severity: Moderate
Cyclobenzaprine and Ombitasvir / paritaprevir / ritonavir and dasabuvir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted regimens induce some enzymes such as CYP1A2 while inhibiting CYP3A4, and cyclobenzaprine is cleared partly by CYP1A2. Cyclobenzaprine levels may fall and its effect may be reduced, although inhibition of other pathways could have the opposite effect.
What this interaction means in plain words
Cyclobenzaprine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probable CYP1A2 induction by the antiviral regimen, with possible mixed effects from CYP3A4 inhibition.
What to do
Monitor response to cyclobenzaprine and increase the dose if clinically needed. Watch for sedation or anticholinergic effects if levels rise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Ombitasvir / paritaprevir / ritonavir and dasabuvir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted regimens induce some enzymes such as CYP1A2 while inhibiting CYP3A4, and cyclobenzaprine is cleared partly by CYP1A2. Cyclobenzaprine levels may fall and its effect may be reduced, although inhibition of other pathways could have the opposite effect.
How serious is the interaction between Cyclobenzaprine and Ombitasvir / paritaprevir / ritonavir and dasabuvir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to cyclobenzaprine and increase the dose if clinically needed. Watch for sedation or anticholinergic effects if levels rise.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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