Drug interactions
Cyclobenzaprine + Orphenadrine
Severity: Moderate
Cyclobenzaprine and Orphenadrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have anticholinergic and sedative properties, so combining them adds to the risk of dry mouth, urinary retention, constipation, blurred vision, confusion and drowsiness. Older adults and patients with glaucoma, prostatic hypertrophy or cognitive impairment are especially vulnerable.
What this interaction means in plain words
Cyclobenzaprine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic and central sedative effects from two centrally acting muscle relaxants with anticholinergic activity.
What to do
Avoid using two muscle relaxants together where possible; if unavoidable, use the lowest doses for the shortest time and monitor for anticholinergic toxicity and sedation. Avoid in elderly patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Orphenadrine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Orphenadrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have anticholinergic and sedative properties, so combining them adds to the risk of dry mouth, urinary retention, constipation, blurred vision, confusion and drowsiness. Older adults and patients with glaucoma, prostatic hypertrophy or cognitive impairment are especially vulnerable.
How serious is the interaction between Cyclobenzaprine and Orphenadrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two muscle relaxants together where possible; if unavoidable, use the lowest doses for the shortest time and monitor for anticholinergic toxicity and sedation. Avoid in elderly patients.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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