Drug interactions
Cyclobenzaprine + Oxybutynin transdermal
Severity: Moderate
Cyclobenzaprine and Oxybutynin transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine has notable anticholinergic activity and oxybutynin is an antimuscarinic that is absorbed systemically from the patch. Together they may add to dry mouth, constipation, urinary retention, blurred vision, drowsiness and confusion.
What this interaction means in plain words
Cyclobenzaprine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic adverse effects, particularly in older patients, and reduce the dose or choose a non-anticholinergic alternative if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Oxybutynin transdermal?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Oxybutynin transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine has notable anticholinergic activity and oxybutynin is an antimuscarinic that is absorbed systemically from the patch. Together they may add to dry mouth, constipation, urinary retention, blurred vision, drowsiness and confusion.
How serious is the interaction between Cyclobenzaprine and Oxybutynin transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic adverse effects, particularly in older patients, and reduce the dose or choose a non-anticholinergic alternative if symptoms occur.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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