Drug interactions
Cyclobenzaprine + Papaveretum
Severity: Major
Cyclobenzaprine and Papaveretum: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Papaveretum is an opium alkaloid mixture, and combining it with the sedating muscle relaxant cyclobenzaprine can deepen sedation and may cause respiratory depression. Impaired psychomotor performance and profound drowsiness are also possible.
What this interaction means in plain words
Cyclobenzaprine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive central nervous system depression from opioid and sedating muscle relaxant activity.
What to do
Use the lowest effective doses and monitor sedation and respiratory rate; counsel patients to avoid driving and alcohol. Consider alternatives if the combination is not essential.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Papaveretum?
MediHelp rates the interaction as major. Cyclobenzaprine and Papaveretum can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Papaveretum is an opium alkaloid mixture, and combining it with the sedating muscle relaxant cyclobenzaprine can deepen sedation and may cause respiratory depression. Impaired psychomotor performance and profound drowsiness are also possible.
How serious is the interaction between Cyclobenzaprine and Papaveretum?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory rate; counsel patients to avoid driving and alcohol. Consider alternatives if the combination is not essential.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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