Drug interactions
Cyclobenzaprine + Rapacuronium
Severity: Minor
Cyclobenzaprine and Rapacuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rapacuronium is a nondepolarizing neuromuscular blocker, and cyclobenzaprine has some muscle relaxant and anticholinergic effects that could modestly add to neuromuscular depression. Rapacuronium has also been withdrawn from most markets, and evidence for this interaction is minimal.
What this interaction means in plain words
Cyclobenzaprine and Rapacuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive effects on neuromuscular function; mechanism is not well established.
What to do
Inform the anesthesia team of cyclobenzaprine use and monitor neuromuscular function with a nerve stimulator during blockade.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Rapacuronium?
MediHelp rates the interaction as minor. Cyclobenzaprine and Rapacuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rapacuronium is a nondepolarizing neuromuscular blocker, and cyclobenzaprine has some muscle relaxant and anticholinergic effects that could modestly add to neuromuscular depression. Rapacuronium has also been withdrawn from most markets, and evidence for this interaction is minimal.
How serious is the interaction between Cyclobenzaprine and Rapacuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team of cyclobenzaprine use and monitor neuromuscular function with a nerve stimulator during blockade.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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