Drug interactions
Cyclobenzaprine + Sage
Severity: Minor
Cyclobenzaprine and Sage: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Some sage species have been reported to cause sedation, so use alongside cyclobenzaprine could theoretically add to drowsiness. The evidence is limited and the effect is probably small.
What this interaction means in plain words
Cyclobenzaprine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive CNS depression; the mechanism is not established.
What to do
Counsel patients to monitor for extra drowsiness and avoid driving if impaired when taking sage supplements with cyclobenzaprine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Sage?
MediHelp rates the interaction as minor. Cyclobenzaprine and Sage have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Some sage species have been reported to cause sedation, so use alongside cyclobenzaprine could theoretically add to drowsiness. The evidence is limited and the effect is probably small.
How serious is the interaction between Cyclobenzaprine and Sage?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to monitor for extra drowsiness and avoid driving if impaired when taking sage supplements with cyclobenzaprine.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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