Drug interactions
Cyclobenzaprine + Scullcap
Severity: Minor
Cyclobenzaprine and Scullcap: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Skullcap is an herbal product traditionally used for its calming effects, and it may add to the sedation caused by cyclobenzaprine. Evidence is limited and product content varies.
What this interaction means in plain words
Cyclobenzaprine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive CNS depression.
What to do
Advise patients to report increased drowsiness and avoid driving if sedated; consider stopping the herbal product if excessive sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Scullcap?
MediHelp rates the interaction as minor. Cyclobenzaprine and Scullcap have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Skullcap is an herbal product traditionally used for its calming effects, and it may add to the sedation caused by cyclobenzaprine. Evidence is limited and product content varies.
How serious is the interaction between Cyclobenzaprine and Scullcap?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to report increased drowsiness and avoid driving if sedated; consider stopping the herbal product if excessive sedation occurs.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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