Drug interactions
Cyclobenzaprine + Topiramate
Severity: Moderate
Cyclobenzaprine and Topiramate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause CNS depression, with drowsiness and dizziness. Cyclobenzaprine also has anticholinergic effects, and topiramate may cause cognitive slowing and confusion. Combined use can impair alertness and psychomotor performance.
What this interaction means in plain words
Cyclobenzaprine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Topiramate belongs to Central Nervous System.
Why it happens
Additive CNS depressant and anticholinergic effects.
What to do
Warn patients about impaired driving and alcohol, and monitor sedation and cognition. Lower the cyclobenzaprine dose or use a short course if sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Topiramate
Frequently asked questions
Can I take Cyclobenzaprine with Topiramate?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Topiramate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause CNS depression, with drowsiness and dizziness. Cyclobenzaprine also has anticholinergic effects, and topiramate may cause cognitive slowing and confusion. Combined use can impair alertness and psychomotor performance.
How serious is the interaction between Cyclobenzaprine and Topiramate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn patients about impaired driving and alcohol, and monitor sedation and cognition. Lower the cyclobenzaprine dose or use a short course if sedation occurs.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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