Drug interactions
Cyclobenzaprine + Trifluoperazine
Severity: Moderate
Cyclobenzaprine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system and have anticholinergic activity, so taking them together can cause more drowsiness, confusion, dry mouth, constipation and urinary retention. Cyclobenzaprine is structurally related to tricyclic antidepressants, so combining it with a phenothiazine may also add to the risk of QT prolongation and lowering of the seizure threshold.
What this interaction means in plain words
Cyclobenzaprine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects, with possible additive effects on cardiac conduction.
What to do
Monitor for excessive sedation, anticholinergic effects and palpitations, and start with the lowest effective doses. Consider an ECG in patients with cardiac risk factors or on other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Trifluoperazine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system and have anticholinergic activity, so taking them together can cause more drowsiness, confusion, dry mouth, constipation and urinary retention. Cyclobenzaprine is structurally related to tricyclic antidepressants, so combining it with a phenothiazine may also add to the risk of QT prolongation and lowering of the seizure threshold.
How serious is the interaction between Cyclobenzaprine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, anticholinergic effects and palpitations, and start with the lowest effective doses. Consider an ECG in patients with cardiac risk factors or on other QT-prolonging drugs.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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