Drug interactions
Cyclopenthiazide + Eprosartan-hydrochlorothiazide
Severity: Moderate
Cyclopenthiazide and Eprosartan-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide is a thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy. This raises the risk of hypokalemia, hyponatremia, hypotension and renal impairment with little added benefit.
What this interaction means in plain words
Cyclopenthiazide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of the distal tubule sodium-chloride cotransporter.
What to do
Avoid using two thiazide diuretics together and stop the duplicate. Check electrolytes and renal function if both were taken.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eprosartan-hydrochlorothiazide
- Aliskiren + Eprosartan-hydrochlorothiazide Contraindicated
- Dofetilide + Eprosartan-hydrochlorothiazide Contraindicated
- Eprosartan-hydrochlorothiazide + Sparsentan Contraindicated
- Aceclofenac + Eprosartan-hydrochlorothiazide Major
- Aldesleukin + Eprosartan-hydrochlorothiazide Major
- Amifostine + Eprosartan-hydrochlorothiazide Major
Frequently asked questions
Can I take Cyclopenthiazide with Eprosartan-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Eprosartan-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclopenthiazide is a thiazide diuretic, so combining it with hydrochlorothiazide duplicates therapy. This raises the risk of hypokalemia, hyponatremia, hypotension and renal impairment with little added benefit.
How serious is the interaction between Cyclopenthiazide and Eprosartan-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two thiazide diuretics together and stop the duplicate. Check electrolytes and renal function if both were taken.
What other medicines interact with Eprosartan-hydrochlorothiazide?
MediHelp also lists interactions of Eprosartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Eprosartan-hydrochlorothiazide page.
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