Drug interactions
Cyclopenthiazide + Gliclazide
Severity: Minor
Cyclopenthiazide and Gliclazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide, a thiazide diuretic, may raise blood glucose and weaken the effect of gliclazide. Clinically significant loss of control is mainly seen with higher doses or long-term use.
What this interaction means in plain words
Cyclopenthiazide and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazide-related hypokalaemia, reduced insulin secretion and decreased insulin sensitivity oppose the sulfonylurea effect.
What to do
Monitor blood glucose when starting or changing the diuretic dose and adjust antidiabetic therapy if control worsens. Monitor potassium.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gliclazide
Frequently asked questions
Can I take Cyclopenthiazide with Gliclazide?
MediHelp rates the interaction as minor. Cyclopenthiazide and Gliclazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclopenthiazide, a thiazide diuretic, may raise blood glucose and weaken the effect of gliclazide. Clinically significant loss of control is mainly seen with higher doses or long-term use.
How serious is the interaction between Cyclopenthiazide and Gliclazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or changing the diuretic dose and adjust antidiabetic therapy if control worsens. Monitor potassium.
What other medicines interact with Gliclazide?
MediHelp also lists interactions of Gliclazide with, for example, Ciprofloxacin, Clarithromycin, Disopyramide. The full list is on the Gliclazide page.
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