Drug interactions
Cyclopenthiazide + Glipizide-metformin
Severity: Moderate
Cyclopenthiazide and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce the effectiveness of antidiabetic drugs. Patients taking glipizide-metformin may lose glycemic control when cyclopenthiazide is added.
What this interaction means in plain words
Cyclopenthiazide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides cause hypokalemia and impair insulin secretion and sensitivity, opposing the glucose-lowering effect of the sulfonylurea and metformin.
What to do
Monitor blood glucose and HbA1c after starting the diuretic and adjust the antidiabetic regimen if needed. Check serum potassium periodically.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Frequently asked questions
Can I take Cyclopenthiazide with Glipizide-metformin?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce the effectiveness of antidiabetic drugs. Patients taking glipizide-metformin may lose glycemic control when cyclopenthiazide is added.
How serious is the interaction between Cyclopenthiazide and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting the diuretic and adjust the antidiabetic regimen if needed. Check serum potassium periodically.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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