Drug interactions
Cyclopenthiazide + Glyburide-metformin
Severity: Moderate
Cyclopenthiazide and Glyburide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics such as cyclopenthiazide can raise blood glucose and may reduce the effect of glyburide and metformin. The effect is generally modest but can matter in poorly controlled diabetes.
What this interaction means in plain words
Cyclopenthiazide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism through thiazide-induced hypokalemia, impaired insulin secretion and increased insulin resistance.
What to do
Monitor blood glucose and HbA1c after starting the thiazide and keep potassium normal. Adjust the antidiabetic regimen if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Frequently asked questions
Can I take Cyclopenthiazide with Glyburide-metformin?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Glyburide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics such as cyclopenthiazide can raise blood glucose and may reduce the effect of glyburide and metformin. The effect is generally modest but can matter in poorly controlled diabetes.
How serious is the interaction between Cyclopenthiazide and Glyburide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting the thiazide and keep potassium normal. Adjust the antidiabetic regimen if control worsens.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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