Drug interactions
Cyclopenthiazide + Ibuprofen
Severity: Moderate
Cyclopenthiazide and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may weaken the diuretic and antihypertensive effect of thiazide-type diuretics. The combination can also increase the risk of renal impairment in volume-depleted patients.
What this interaction means in plain words
Cyclopenthiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ibuprofen inhibits renal prostaglandin synthesis, causing sodium and water retention and decreased renal perfusion.
What to do
Monitor blood pressure, fluid status and renal function, and use the lowest effective NSAID dose briefly. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Cyclopenthiazide with Ibuprofen?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen may weaken the diuretic and antihypertensive effect of thiazide-type diuretics. The combination can also increase the risk of renal impairment in volume-depleted patients.
How serious is the interaction between Cyclopenthiazide and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status and renal function, and use the lowest effective NSAID dose briefly. Consider paracetamol as an alternative.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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