Drug interactions
Cyclopenthiazide + Insulin glulisine
Severity: Moderate
Cyclopenthiazide and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide, a thiazide diuretic, may raise blood glucose and reduce the effect of insulin. Insulin requirements may rise, particularly at higher doses.
What this interaction means in plain words
Cyclopenthiazide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and impaired insulin secretion and sensitivity oppose insulin action.
What to do
Monitor blood glucose and serum potassium, and adjust the insulin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin glulisine
Frequently asked questions
Can I take Cyclopenthiazide with Insulin glulisine?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclopenthiazide, a thiazide diuretic, may raise blood glucose and reduce the effect of insulin. Insulin requirements may rise, particularly at higher doses.
How serious is the interaction between Cyclopenthiazide and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium, and adjust the insulin dose as needed.
What other medicines interact with Insulin glulisine?
MediHelp also lists interactions of Insulin glulisine with, for example, Alogliptin-pioglitazone, Ethanol, Pentamidine. The full list is on the Insulin glulisine page.
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