Drug interactions
Cyclopenthiazide + Meloxicam
Severity: Moderate
Cyclopenthiazide and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam may blunt the diuretic and antihypertensive action of cyclopenthiazide and raises the risk of renal impairment in volume-depleted patients.
What this interaction means in plain words
Cyclopenthiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium retention and reduced renal perfusion.
What to do
Monitor blood pressure, fluid status, creatinine and electrolytes; ensure hydration and use the lowest NSAID dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Cyclopenthiazide with Meloxicam?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meloxicam may blunt the diuretic and antihypertensive action of cyclopenthiazide and raises the risk of renal impairment in volume-depleted patients.
How serious is the interaction between Cyclopenthiazide and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, fluid status, creatinine and electrolytes; ensure hydration and use the lowest NSAID dose.
What other medicines interact with Meloxicam?
MediHelp also lists interactions of Meloxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Meloxicam page.
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