Drug interactions
Cyclopenthiazide + Naproxen
Severity: Moderate
Cyclopenthiazide and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naproxen can attenuate the antihypertensive and diuretic effects of cyclopenthiazide. The combination may also increase the risk of renal impairment, especially with dehydration.
What this interaction means in plain words
Cyclopenthiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium and water retention and reduced renal perfusion.
What to do
Monitor blood pressure, renal function and electrolytes, and keep the patient well hydrated. Limit the duration of NSAID therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Cyclopenthiazide with Naproxen?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Naproxen can attenuate the antihypertensive and diuretic effects of cyclopenthiazide. The combination may also increase the risk of renal impairment, especially with dehydration.
How serious is the interaction between Cyclopenthiazide and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and keep the patient well hydrated. Limit the duration of NSAID therapy.
What other medicines interact with Naproxen?
MediHelp also lists interactions of Naproxen with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Naproxen page.
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