Drug interactions
Cyclopenthiazide + Repaglinide
Severity: Moderate
Cyclopenthiazide and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide, a thiazide diuretic, may raise blood glucose and weaken the effect of repaglinide. Clinical significance is usually modest at low doses.
What this interaction means in plain words
Cyclopenthiazide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazide-induced hypokalemia and impaired insulin secretion oppose repaglinide.
What to do
Monitor blood glucose and potassium and increase the antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporin + Repaglinide Major
- Deferasirox + Repaglinide Major
Frequently asked questions
Can I take Cyclopenthiazide with Repaglinide?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclopenthiazide, a thiazide diuretic, may raise blood glucose and weaken the effect of repaglinide. Clinical significance is usually modest at low doses.
How serious is the interaction between Cyclopenthiazide and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium and increase the antidiabetic therapy if control worsens.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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