Drug interactions
Cyclopenthiazide + Sacubitril-valsartan
Severity: Moderate
Cyclopenthiazide and Sacubitril-valsartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This thiazide lowers potassium while valsartan raises it, so the net effect is variable. The combination adds to blood pressure lowering and may cause volume depletion or renal changes.
What this interaction means in plain words
Cyclopenthiazide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive and volume-depleting effects with opposing effects on potassium excretion.
What to do
Monitor blood pressure, renal function and electrolytes after starting or adjusting either drug. Reduce the diuretic dose if hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclopenthiazide and Sacubitril-valsartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Sacubitril-valsartan
- Aliskiren + Sacubitril-valsartan Contraindicated
- Benazepril + Sacubitril-valsartan Contraindicated
- Captopril + Sacubitril-valsartan Contraindicated
- Enalapril + Sacubitril-valsartan Contraindicated
- Fosinopril + Sacubitril-valsartan Contraindicated
- Lisinopril + Sacubitril-valsartan Contraindicated
Frequently asked questions
Can I take Cyclopenthiazide with Sacubitril-valsartan?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Sacubitril-valsartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. This thiazide lowers potassium while valsartan raises it, so the net effect is variable. The combination adds to blood pressure lowering and may cause volume depletion or renal changes.
How serious is the interaction between Cyclopenthiazide and Sacubitril-valsartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or adjusting either drug. Reduce the diuretic dose if hypotension develops.
What other medicines interact with Sacubitril-valsartan?
MediHelp also lists interactions of Sacubitril-valsartan with, for example, Aliskiren, Benazepril, Captopril. The full list is on the Sacubitril-valsartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
