Drug interactions
Cyclopenthiazide + Salbutamol
Severity: Moderate
Cyclopenthiazide and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lower serum potassium. Together, particularly with high-dose or nebulised salbutamol, hypokalemia may be more pronounced and may predispose to cardiac arrhythmias.
What this interaction means in plain words
Cyclopenthiazide and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salbutamol shifts potassium into cells via beta-2 stimulation of Na/K-ATPase, while thiazide diuretics increase renal potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium, especially with high-dose or repeated salbutamol use or in patients with cardiac disease. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Frequently asked questions
Can I take Cyclopenthiazide with Salbutamol?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can lower serum potassium. Together, particularly with high-dose or nebulised salbutamol, hypokalemia may be more pronounced and may predispose to cardiac arrhythmias.
How serious is the interaction between Cyclopenthiazide and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, especially with high-dose or repeated salbutamol use or in patients with cardiac disease. Replace potassium as needed.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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