Drug interactions
Cyclopenthiazide + Salmeterol
Severity: Moderate
Cyclopenthiazide and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower serum potassium, and together the effect may be additive. Hypokalemia can predispose to cardiac arrhythmias, particularly in patients with cardiac disease or hypoxia.
What this interaction means in plain words
Cyclopenthiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-2 agonists shift potassium into cells while thiazide diuretics increase renal potassium loss, producing additive hypokalemia.
What to do
Monitor serum potassium and magnesium periodically, especially at the start of therapy or in patients with severe asthma or COPD. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Frequently asked questions
Can I take Cyclopenthiazide with Salmeterol?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower serum potassium, and together the effect may be additive. Hypokalemia can predispose to cardiac arrhythmias, particularly in patients with cardiac disease or hypoxia.
How serious is the interaction between Cyclopenthiazide and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium periodically, especially at the start of therapy or in patients with severe asthma or COPD. Replace potassium as needed.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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