Drug interactions
Cyclopenthiazide + Tolvaptan
Severity: Moderate
Cyclopenthiazide and Tolvaptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics lower serum potassium and sodium, while tolvaptan raises sodium and may raise potassium. Combined use can produce unpredictable electrolyte changes and volume depletion.
What this interaction means in plain words
Cyclopenthiazide and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic: thiazide natriuresis and potassium loss together with tolvaptan aquaresis and potassium-raising effect.
What to do
Monitor serum sodium, potassium and hydration status during initiation and dose changes. Adjust therapy if sodium correction is too rapid or potassium becomes abnormal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tolvaptan
- Atazanavir + Tolvaptan Contraindicated
- Ceritinib + Tolvaptan Contraindicated
- Cobicistat + Tolvaptan Contraindicated
- Conivaptan + Tolvaptan Contraindicated
- Darunavir + Tolvaptan Contraindicated
- Idelalisib + Tolvaptan Contraindicated
Frequently asked questions
Can I take Cyclopenthiazide with Tolvaptan?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Tolvaptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics lower serum potassium and sodium, while tolvaptan raises sodium and may raise potassium. Combined use can produce unpredictable electrolyte changes and volume depletion.
How serious is the interaction between Cyclopenthiazide and Tolvaptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum sodium, potassium and hydration status during initiation and dose changes. Adjust therapy if sodium correction is too rapid or potassium becomes abnormal.
What other medicines interact with Tolvaptan?
MediHelp also lists interactions of Tolvaptan with, for example, Atazanavir, Ceritinib, Cobicistat. The full list is on the Tolvaptan page.
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