Drug interactions
Cyclopenthiazide + Triamterene
Severity: Minor
Cyclopenthiazide and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide causes potassium loss while triamterene retains it, so the two offset each other. Potassium can still become too low or too high, particularly with renal impairment.
What this interaction means in plain words
Cyclopenthiazide and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing renal potassium handling: thiazide-induced kaliuresis versus ENaC blockade by triamterene.
What to do
Monitor serum potassium and sodium periodically, especially after starting therapy and with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Cyclopenthiazide with Triamterene?
MediHelp rates the interaction as minor. Cyclopenthiazide and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclopenthiazide causes potassium loss while triamterene retains it, so the two offset each other. Potassium can still become too low or too high, particularly with renal impairment.
How serious is the interaction between Cyclopenthiazide and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and sodium periodically, especially after starting therapy and with renal impairment.
What other medicines interact with Triamterene?
MediHelp also lists interactions of Triamterene with, for example, Amiloride, Eplerenone, Potassium citrate / citric acid. The full list is on the Triamterene page.
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