Drug interactions
Cyclophosphamide + Dabrafenib
Severity: Moderate
Cyclophosphamide and Dabrafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and CYP2B6, which may alter metabolic activation of cyclophosphamide. Exposure to active metabolites could increase, with possible greater toxicity or changed efficacy. Clinical data are limited.
What this interaction means in plain words
Cyclophosphamide and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Dabrafenib belongs to Oncology.
Why it happens
Induction of CYP3A4 and CYP2B6 by dabrafenib changes cyclophosphamide metabolism.
What to do
Monitor blood counts and clinical response closely when the two are combined. Adjust cyclophosphamide only based on observed toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Dabrafenib
Frequently asked questions
Can I take Cyclophosphamide with Dabrafenib?
MediHelp rates the interaction as moderate. Cyclophosphamide and Dabrafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and CYP2B6, which may alter metabolic activation of cyclophosphamide. Exposure to active metabolites could increase, with possible greater toxicity or changed efficacy. Clinical data are limited.
How serious is the interaction between Cyclophosphamide and Dabrafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and clinical response closely when the two are combined. Adjust cyclophosphamide only based on observed toxicity.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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