Drug interactions
Cyclophosphamide + Dacarbazine
Severity: Moderate
Cyclophosphamide and Dacarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are myelosuppressive, so combined use raises the risk of neutropenia, thrombocytopenia and infection. Dacarbazine can also cause liver toxicity.
What this interaction means in plain words
Cyclophosphamide and Dacarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Dacarbazine belongs to Oncology.
Why it happens
Additive bone marrow suppression from two cytotoxic agents.
What to do
Monitor complete blood counts and liver tests, and modify doses or delay cycles for significant cytopenias.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclophosphamide and Dacarbazine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclophosphamide
Other interactions of Dacarbazine
Frequently asked questions
Can I take Cyclophosphamide with Dacarbazine?
MediHelp rates the interaction as moderate. Cyclophosphamide and Dacarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are myelosuppressive, so combined use raises the risk of neutropenia, thrombocytopenia and infection. Dacarbazine can also cause liver toxicity.
How serious is the interaction between Cyclophosphamide and Dacarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and liver tests, and modify doses or delay cycles for significant cytopenias.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
