Drug interactions
Cyclophosphamide + Danazol
Severity: Minor
Cyclophosphamide and Danazol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a weak CYP3A4 inhibitor and might slow the activation of cyclophosphamide, which depends partly on CYP2B6 and CYP3A4 hepatic enzymes. The net clinical effect on exposure to the active metabolites is uncertain and probably small.
What this interaction means in plain words
Cyclophosphamide and Danazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak inhibition of CYP-mediated bioactivation of cyclophosphamide by danazol; not firmly established.
What to do
No dose change is needed; monitor the usual blood counts and response to cyclophosphamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Danazol?
MediHelp rates the interaction as minor. Cyclophosphamide and Danazol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a weak CYP3A4 inhibitor and might slow the activation of cyclophosphamide, which depends partly on CYP2B6 and CYP3A4 hepatic enzymes. The net clinical effect on exposure to the active metabolites is uncertain and probably small.
How serious is the interaction between Cyclophosphamide and Danazol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor the usual blood counts and response to cyclophosphamide.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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