Drug interactions
Cyclophosphamide + Erythromycin stearate
Severity: Minor
Cyclophosphamide and Erythromycin stearate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin inhibits CYP3A4 and may alter cyclophosphamide metabolism, affecting both activation and formation of toxic by-products. The net clinical effect is uncertain and likely small.
What this interaction means in plain words
Cyclophosphamide and Erythromycin stearate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Erythromycin CYP3A4 inhibition may alter cyclophosphamide metabolic pathways; net effect is not well established.
What to do
No empirical dose change; monitor for myelosuppression and treatment response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Erythromycin stearate?
MediHelp rates the interaction as minor. Cyclophosphamide and Erythromycin stearate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Erythromycin inhibits CYP3A4 and may alter cyclophosphamide metabolism, affecting both activation and formation of toxic by-products. The net clinical effect is uncertain and likely small.
How serious is the interaction between Cyclophosphamide and Erythromycin stearate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor for myelosuppression and treatment response.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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