Drug interactions
Cyclophosphamide + Fexinidazole
Severity: Moderate
Cyclophosphamide and Fexinidazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole may induce CYP2B6 and inhibit CYP3A4, which are enzymes involved in cyclophosphamide activation and in its side-pathway metabolism. Exposure to active metabolites could therefore change unpredictably, altering efficacy or toxicity.
What this interaction means in plain words
Cyclophosphamide and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing effects on cyclophosphamide metabolism: CYP2B6 induction and CYP3A4 inhibition.
What to do
Avoid the combination if possible. If both are required, monitor for cyclophosphamide toxicity such as myelosuppression and for reduced response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Fexinidazole?
MediHelp rates the interaction as moderate. Cyclophosphamide and Fexinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fexinidazole may induce CYP2B6 and inhibit CYP3A4, which are enzymes involved in cyclophosphamide activation and in its side-pathway metabolism. Exposure to active metabolites could therefore change unpredictably, altering efficacy or toxicity.
How serious is the interaction between Cyclophosphamide and Fexinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If both are required, monitor for cyclophosphamide toxicity such as myelosuppression and for reduced response.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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