Drug interactions
Cyclophosphamide + Heparin
Severity: Moderate
Cyclophosphamide and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide-induced thrombocytopenia increases the risk of bleeding in patients receiving heparin. Heparin itself can cause heparin-induced thrombocytopenia, which complicates platelet interpretation.
What this interaction means in plain words
Cyclophosphamide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Heparin belongs to Cardiovascular.
Why it happens
Additive bleeding risk from chemotherapy-induced thrombocytopenia combined with anticoagulation.
What to do
Monitor platelet counts and coagulation parameters (aPTT or anti-Xa), and adjust or interrupt heparin if platelets drop markedly or bleeding develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Cyclophosphamide with Heparin?
MediHelp rates the interaction as moderate. Cyclophosphamide and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclophosphamide-induced thrombocytopenia increases the risk of bleeding in patients receiving heparin. Heparin itself can cause heparin-induced thrombocytopenia, which complicates platelet interpretation.
How serious is the interaction between Cyclophosphamide and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and coagulation parameters (aPTT or anti-Xa), and adjust or interrupt heparin if platelets drop markedly or bleeding develops.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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