Drug interactions
Cyclophosphamide + Hydrochlorothiazide-olmesartan
Severity: Moderate
Cyclophosphamide and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may increase myelosuppression from cyclophosphamide, with deeper or longer neutropenia reported. The effect is clinically relevant mainly during chemotherapy cycles.
What this interaction means in plain words
Cyclophosphamide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Thiazides are thought to reduce renal clearance of cyclophosphamide or its metabolites, increasing marrow exposure; the mechanism is not fully established.
What to do
Monitor complete blood counts closely during cyclophosphamide cycles. Consider an alternative antihypertensive if neutropenia is pronounced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclophosphamide and Hydrochlorothiazide-olmesartan, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Cyclophosphamide and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may increase myelosuppression from cyclophosphamide, with deeper or longer neutropenia reported. The effect is clinically relevant mainly during chemotherapy cycles.
How serious is the interaction between Cyclophosphamide and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely during cyclophosphamide cycles. Consider an alternative antihypertensive if neutropenia is pronounced.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
