Drug interactions
Cyclophosphamide + Indinavir
Severity: Moderate
Cyclophosphamide and Indinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indinavir inhibits CYP3A4 and may alter how cyclophosphamide is converted to its active and inactive metabolites. The direction and size of the clinical effect are uncertain, but changes in exposure could affect either efficacy or toxicity.
What this interaction means in plain words
Cyclophosphamide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by indinavir may modify cyclophosphamide metabolism.
What to do
Monitor blood counts and for signs of cyclophosphamide toxicity such as infection, mucositis and hemorrhagic cystitis. Consider an alternative antiretroviral without CYP3A4 inhibition if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Indinavir?
MediHelp rates the interaction as moderate. Cyclophosphamide and Indinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indinavir inhibits CYP3A4 and may alter how cyclophosphamide is converted to its active and inactive metabolites. The direction and size of the clinical effect are uncertain, but changes in exposure could affect either efficacy or toxicity.
How serious is the interaction between Cyclophosphamide and Indinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of cyclophosphamide toxicity such as infection, mucositis and hemorrhagic cystitis. Consider an alternative antiretroviral without CYP3A4 inhibition if feasible.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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