Drug interactions
Cyclophosphamide + Influenza virus vaccine adjuvanted
Severity: Moderate
Cyclophosphamide and Influenza virus vaccine adjuvanted: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide-induced immunosuppression can reduce the antibody response to the adjuvanted H5N1 influenza vaccine, so protection may be incomplete. The vaccine is inactivated, so the concern is reduced efficacy rather than vaccine-related infection.
What this interaction means in plain words
Cyclophosphamide and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cytotoxic suppression of lymphocyte function reduces vaccine immunogenicity.
What to do
Vaccinate before starting cyclophosphamide when possible, or time doses to the period of immune recovery between cycles. Consider assessing response or additional doses if the patient remains at high risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Influenza virus vaccine adjuvanted?
MediHelp rates the interaction as moderate. Cyclophosphamide and Influenza virus vaccine adjuvanted can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclophosphamide-induced immunosuppression can reduce the antibody response to the adjuvanted H5N1 influenza vaccine, so protection may be incomplete. The vaccine is inactivated, so the concern is reduced efficacy rather than vaccine-related infection.
How serious is the interaction between Cyclophosphamide and Influenza virus vaccine adjuvanted?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate before starting cyclophosphamide when possible, or time doses to the period of immune recovery between cycles. Consider assessing response or additional doses if the patient remains at high risk.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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