Drug interactions
Cyclophosphamide + Lumacaftor / ivacaftor
Severity: Moderate
Cyclophosphamide and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor is an inducer of CYP enzymes and may increase cyclophosphamide activation, potentially raising exposure to toxic active metabolites, while ivacaftor may inhibit CYP2B6 in vitro. The overall effect is uncertain.
What this interaction means in plain words
Cyclophosphamide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Lumacaftor-mediated CYP induction and ivacaftor CYP2B6 inhibition may alter cyclophosphamide bioactivation (based on in vitro data).
What to do
Monitor blood counts and for toxicity or reduced therapeutic response during concurrent use. No standard dose adjustment exists.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Cyclophosphamide and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor is an inducer of CYP enzymes and may increase cyclophosphamide activation, potentially raising exposure to toxic active metabolites, while ivacaftor may inhibit CYP2B6 in vitro. The overall effect is uncertain.
How serious is the interaction between Cyclophosphamide and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for toxicity or reduced therapeutic response during concurrent use. No standard dose adjustment exists.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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